24 Aug

Brand new Brand for NPSC

I’ve been working with Den Barrault, the Executive Director of SULSA and a design company in Edinburgh, called Moriarti Design, to help create a brand, marketing material and websign for NPSC. This has been a really interesting process and after much deliberation we now have the final design on our signage.

NPSC logo

 

 

 

 

The idea was to allude to the identification of specific objects (which could be cells or groups of cells even) in a sample (e.g. in the well bottom of a plate) as indicated by the circles but also the colours. The size of the circles are also different to indicate the magnitude of a signal (or could be a literal reflection of cell size).Some people even see it as a sphere, which is interesting as hopefully we will be doing quite a few 3D phenotypic assays.

The feedback has all been really positive!

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24 Aug

Time flies when you are having fun!

I thought it would be a good idea to refresh this site since it’s been rather a long time.

Well the National Phenotypic Screening Centre is now up and running! It’s been a long process but great fun as well as a great deal of hard work. THe installation of the automation, readers and the other lab infrastructure was delayed due to the contractors who handed over the site to us only in February 2015.

We hired our Lead Engineer in December 2014 (John Raynor) who we poached from the SGC in Oxford. He has been a huge help and is looking after both robot systems and the other devices which touch-wood are behaving pretty well.

The main focus at the moment is getting the biology going with some and making sure the general workflows are robust.

Here are some pics of the equipment in situ.

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24 Sep

Greetings from Boston

Factory Acceptance testing of the two systems destined for Dundee is underway at the  High Res Bio factory on the outskirts of Boston. So far all is going well. One system (shown in the first video below) is based around a six-sided Microstar, with dockable carts containing the peripheral devices, in the video you can see the Echo 550 acoustic dispenser and the Enspire label-free plate reader. The larger system has 9-sides and even more devices (see the second video). I think it’s safe to say these are impressive automation systems!

They also have very cool fish here too…

16 Aug

UK-NPSC progress updates

Progress towards establishing the centres in Oxford and Dundee is going well. The building work required for the Dundee site is about to begin in earnest with a completion date in late October.  The Oxford equipment is on its return journey across the big pond after successful factory acceptance testing in Boston – installations will start 22nd September!

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The two Dundee systems are being assembled at this very moment at the High Res Bio factory in Woburn,  MA.  I’ll be there to supervise the factory acceptance test over the last week of September.

There is more information about the UK-NPSC, its focus and the equipment that will be used at both sites can be found at the fledgling UK-NPSC website.

You can also follow UK-NPSC on twitter @uknpsc

High Res Biosolutions Inc. the robotics and automation providers for the centre have  also made a press release describing their involvement.

08 May

Stem Cell Solutions and the UK-NPSC

I am pleased to be able to reveal that the major project Stem Cell Solutions Ltd has been heavily involved in since May 2013 has been the creation of the UK National Phenotypic Screening Centre (UK-NPSC). This project was given a major boost with a recently announced £8M infrastructure award from the Scottish Government.

The UK National Phenotypic Screening Centre will focus on directly screening chemical agents against human cells and tissues to identify compounds that combat a disease. Phenotypic screening is thought to be a powerful method for drug discovery because it offers the opportunity to go beyond the focus on single drug targets, traditionally the most widely adopted approach for drug discovery.

The currently favoured model for drug discovery, focussing on a single target, has been plagued by low success rates in pre-clinical development, as well as expensive late-stage failure of many  drugs in phase 2 and 3 clinical trials. The key aim of UK-NPSC will be to capitalise on recent advances in more physiologically-relevant  human cell and organ culture systems, genome engineering, human stem cells (hESC & hiPSC), high-content screening with multiparametric phenotypic analysis to provide a non-biased, disease and patient-contextualised approach to drug discovery.

The project has been spearheaded by the Scottish Universities Life Science Alliance (SULSA) SULSA-logowho recently selected the University of Dundee’s College of Life Sciences to host the main screening centre with a second unit embedded in the University of Oxford’s Target Discovery Institute.

“The Scottish Universities Life Sciences Alliance (SULSA) has determined that the University of Dundee will host the centre and it will work with some of Europe’s top pharmaceutical companies to form a large public-private partnership in the field of novel therapy research and development, adding further strength to Scotland’s position in the field.”  Michael Russell, Cabinet Secretary for Education.

“Professor Andrew Hopkins, Director of SULSA and a member of the College’s Division of Biological Chemistry and Drug Discovery, deserves enormous credit for securing this funding that will transform the landscape of drug discovery capabilities in the UK.”  Professor Mike Ferguson CBE, FRS, FRSE, FMedSci,  Dean of Research at the College of Life Sciences.

This continues to be an really exciting project to be involved in, having been on board since the very early stages performing the ground work which kick-started the project. This has included all the early scoping exercises (including visits to world-class centres of excellence) and all the technical evaluations.  As part of the core writing team (the Director of SULSA, Professor Andrew Hopkins and Executive Director of SULSA, Dr. Den Barrault, a second independent consultant Dr. Wilma Keighley and with additional input from Dr. Neil Carragher a phenotypic screening group leader in Edinburgh Cancer Research Centre)  we generated a white-paper, then a fully developed, costed, proposal. This led to the infrastructure award to allow the purchasing of state-of-the art screening equipment and a significant investment in high performance computing. Phase II to develop the UK network and sign up consortium members. Currently I am managing the establishment of the facility,  which we hope to have fully operational by the end of 2014.

The announcement has been covered on various news outlets including the BBC, STV and local Press. SULSA’s press release can be view here.

Watch this space for more developments.

08 Apr

Editorial Board Membership News

I’m pleased to be able to announce I’ve been invited to be an editorial board member for Current Research in Drug Discovery. Please submit your latest and greatest work to this new, open-access, peer-reviewed, journal. crdd

My areas of responsibility include:
Screening technologies, target identification and validation, laboratory automation, assay development and validation, high content analysis, data mining, biomarkers discovery, biobanking, cell based assays, use of stem cells in drug discovery, iPS-disease modelling, phenotypic screening.

Current Research in Drug Discovery publishes original research papers and review articles on drug discovery and development. Specific areas of interest include screening technologies, target and lead identification and validation, laboratory automation, high throughput screening, assay development and validation, high content analysis, data mining, biomarkers discovery and ADME.

CRDD is media partner for the following events and will be attended by the Editor-in-Chief Giancarlo Basile:

European Laboratory Automation, High Content Analysis, Advances In Cellular Assay and Cell Culture May 13-15, 2014 Barcelona
World Pharma Congress May 21-24, 2014 Boston US
Drug Discovery and Development June 17-18, 2014 (Online Event)
Drug Discovery India, Drug Metabolism and Discovery ADMET September 11-12, 2014 Mumbai India
Discovery On Target October 8-10, 2014 Boston US

Moreover CRDD is partner of MolBase:

25 Mar

Welcome to Stem Cell Solutions

Stem Cell Solutions Ltd. is an independent UK-based consultancy company established in 2013 by Dr Paul Andrews. We offer a range of services for academic and industrial clients tailored to your needs, whether modest one-off consultancy work or highly ambitious long term national or global projects. Please explore the site and find out how we can help you.

SCS platform

Robust industrial platform for screening stem cells